:root {
  --bg: #f3f7fc;
  --surface: #ffffff;
  --surface-soft: #f8fbff;
  --text: #16243a;
  --muted: #60708a;
  --border: #d9e3f0;
  --primary: #2168d5;
  --primary-dark: #174ca2;
  --green: #15805a;
  --green-soft: #eaf8f2;
  --yellow: #a46c00;
  --yellow-soft: #fff7df;
  --red: #b62d35;
  --red-soft: #fff0f1;
  --neutral-soft: #eef2f7;
  --shadow: 0 18px 48px rgba(27, 61, 105, .10);
  --radius: 22px;
}

.dark {
  --bg: #0d1727;
  --surface: #142136;
  --surface-soft: #182840;
  --text: #eef5ff;
  --muted: #a9b9cf;
  --border: #2c3d57;
  --primary: #6da4ff;
  --primary-dark: #a9c8ff;
  --green-soft: rgba(21,128,90,.18);
  --yellow-soft: rgba(164,108,0,.20);
  --red-soft: rgba(182,45,53,.18);
  --neutral-soft: #21324a;
  --shadow: 0 18px 48px rgba(0,0,0,.24);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  background: var(--bg);
  color: var(--text);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  line-height: 1.55;
}
button, input, select { font: inherit; }
a { color: var(--primary); }
[hidden] { display: none !important; }

.calped-shell { width: min(1180px, calc(100% - 28px)); margin-inline: auto; }
.calped-header {
  position: sticky;
  top: 0;
  z-index: 30;
  border-bottom: 1px solid var(--border);
  background: color-mix(in srgb, var(--surface) 92%, transparent);
  backdrop-filter: blur(15px);
}
.brand-mark {
  display: grid;
  place-items: center;
  width: 46px;
  height: 46px;
  border-radius: 15px;
  background: linear-gradient(135deg, var(--primary), #44a1ff);
  color: #fff;
  font-size: 1.4rem;
  font-weight: 900;
  box-shadow: 0 10px 25px rgba(33,104,213,.28);
}
.header-link { color: var(--muted); text-decoration: none; font-weight: 700; }
.header-link:hover { color: var(--primary); }

.hero {
  padding: 34px 0 22px;
  display: grid;
  gap: 18px;
}
.eyebrow {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  width: fit-content;
  padding: 7px 11px;
  border-radius: 999px;
  background: #e9f2ff;
  color: #1554ad;
  font-size: .78rem;
  font-weight: 900;
  letter-spacing: .02em;
}
.dark .eyebrow { background: rgba(109,164,255,.14); color: #a9c8ff; }
.hero h1 { margin: 0; font-size: clamp(2rem, 5vw, 3.35rem); line-height: 1.05; letter-spacing: -.045em; }
.hero p { margin: 8px 0 0; max-width: 880px; color: var(--muted); font-size: 1.04rem; }

.card {
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
}
.card-soft {
  background: var(--surface-soft);
  border: 1px solid var(--border);
  border-radius: 18px;
}

.disclaimer {
  display: flex;
  gap: 12px;
  align-items: flex-start;
  padding: 15px 17px;
  border: 1px solid #efd58a;
  background: var(--yellow-soft);
  border-radius: 18px;
  color: var(--text);
}
.disclaimer strong { color: var(--yellow); }

.tab-nav {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 9px;
  padding: 9px;
  margin: 20px 0;
  background: var(--surface);
  border: 1px solid var(--border);
  border-radius: 20px;
  box-shadow: var(--shadow);
}
.tab-button {
  min-height: 62px;
  border: 0;
  border-radius: 15px;
  background: transparent;
  color: var(--muted);
  cursor: pointer;
  padding: 10px 12px;
  text-align: left;
  font-weight: 850;
  transition: .18s ease;
}
.tab-button span { display: block; font-size: .72rem; font-weight: 700; opacity: .85; margin-top: 2px; }
.tab-button:hover { background: var(--surface-soft); color: var(--text); }
.tab-button.active { background: var(--primary); color: #fff; box-shadow: 0 10px 22px rgba(33,104,213,.25); }

.tab-panel { animation: panelIn .22s ease; }
@keyframes panelIn { from { opacity: .2; transform: translateY(6px); } to { opacity: 1; transform: none; } }

.section-card { padding: clamp(18px, 3vw, 30px); margin-bottom: 20px; }
.section-heading { display: flex; gap: 13px; align-items: flex-start; margin-bottom: 20px; }
.section-number {
  display: grid;
  place-items: center;
  min-width: 38px;
  height: 38px;
  border-radius: 13px;
  background: #e9f2ff;
  color: var(--primary-dark);
  font-weight: 950;
}
.dark .section-number { background: rgba(109,164,255,.15); }
.section-heading h2 { margin: 0; font-size: 1.35rem; letter-spacing: -.02em; }
.section-heading p { margin: 3px 0 0; color: var(--muted); font-size: .94rem; }

.field-label { display: block; margin-bottom: 7px; font-size: .87rem; font-weight: 850; }
.field-help { margin: 7px 0 0; color: var(--muted); font-size: .78rem; }
.form-control {
  width: 100%;
  min-height: 48px;
  border: 1px solid var(--border);
  border-radius: 13px;
  background: var(--surface);
  color: var(--text);
  padding: 10px 12px;
  outline: none;
  transition: border-color .16s ease, box-shadow .16s ease;
}
.form-control:focus { border-color: var(--primary); box-shadow: 0 0 0 4px rgba(33,104,213,.12); }
.field-error { border-color: var(--red) !important; box-shadow: 0 0 0 4px rgba(182,45,53,.12) !important; }

.btn-primary, .btn-secondary, .btn-danger {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  gap: 8px;
  min-height: 46px;
  border-radius: 13px;
  padding: 10px 16px;
  font-weight: 900;
  cursor: pointer;
  text-decoration: none;
  border: 1px solid transparent;
}
.btn-primary { background: var(--primary); color: #fff; box-shadow: 0 10px 22px rgba(33,104,213,.22); }
.btn-primary:hover { filter: brightness(.96); }
.btn-secondary { background: var(--surface); color: var(--text); border-color: var(--border); }
.btn-secondary:hover { border-color: var(--primary); color: var(--primary); }
.btn-danger { background: var(--red-soft); color: var(--red); border-color: color-mix(in srgb, var(--red) 30%, var(--border)); }

.global-message {
  margin: 14px 0;
  padding: 13px 15px;
  border-radius: 14px;
  border: 1px solid var(--border);
  font-weight: 750;
}
.global-message.error { background: var(--red-soft); color: var(--red); border-color: color-mix(in srgb, var(--red) 35%, var(--border)); }
.global-message.success { background: var(--green-soft); color: var(--green); border-color: color-mix(in srgb, var(--green) 35%, var(--border)); }

.clinical-grid { display: grid; grid-template-columns: repeat(3, minmax(0,1fr)); gap: 12px; }
.clinical-option {
  position: relative;
  display: block;
  min-height: 180px;
  padding: 17px;
  border: 2px solid var(--border);
  border-radius: 18px;
  background: var(--surface-soft);
  cursor: pointer;
  transition: .18s ease;
}
.clinical-option input { position: absolute; opacity: 0; pointer-events: none; }
.clinical-option:has(input:checked) { border-color: var(--option-color); box-shadow: 0 0 0 4px color-mix(in srgb, var(--option-color) 16%, transparent); background: color-mix(in srgb, var(--option-color) 8%, var(--surface)); }
.clinical-dot { width: 13px; height: 13px; border-radius: 50%; background: var(--option-color); display: inline-block; }
.clinical-option h3 { margin: 8px 0; font-size: 1rem; }
.clinical-option p { margin: 0; color: var(--muted); font-size: .86rem; }

.result-box { padding: 20px; border-radius: 20px; border: 1px solid var(--border); background: var(--surface-soft); }
.result-box[data-level="green"] { border-color: color-mix(in srgb, var(--green) 42%, var(--border)); background: var(--green-soft); }
.result-box[data-level="yellow"] { border-color: color-mix(in srgb, var(--yellow) 42%, var(--border)); background: var(--yellow-soft); }
.result-box[data-level="red"] { border-color: color-mix(in srgb, var(--red) 42%, var(--border)); background: var(--red-soft); }
.result-metrics { display: grid; grid-template-columns: repeat(3, minmax(0,1fr)); gap: 12px; margin: 16px 0; }
.metric { padding: 14px; background: color-mix(in srgb, var(--surface) 82%, transparent); border: 1px solid var(--border); border-radius: 15px; }
.metric span { display: block; color: var(--muted); font-size: .76rem; font-weight: 750; }
.metric strong { display: block; margin-top: 4px; font-size: 1.25rem; line-height: 1.15; }

.reference-details { margin-top: 13px; border-top: 1px solid var(--border); padding-top: 11px; }
.reference-details summary { cursor: pointer; color: var(--primary); font-weight: 850; }
.reference-details > div { padding-top: 9px; color: var(--muted); font-size: .86rem; }
.reference-details p { margin: 5px 0; }

.rodwell-list { display: grid; gap: 10px; }
.rodwell-item {
  display: grid;
  grid-template-columns: 26px 1fr;
  gap: 11px;
  align-items: flex-start;
  padding: 14px;
  border: 1px solid var(--border);
  border-radius: 15px;
  background: var(--surface-soft);
  cursor: pointer;
}
.rodwell-item input { width: 20px; height: 20px; accent-color: var(--primary); margin-top: 2px; }
.rodwell-item strong { display: block; font-size: .93rem; }
.rodwell-item small { display: block; margin-top: 3px; color: var(--muted); }
.rodwell-result { display: grid; gap: 8px; padding: 20px; border-radius: 18px; border: 1px solid var(--border); background: var(--neutral-soft); }
.rodwell-result[data-status="normal"] { background: var(--green-soft); border-color: color-mix(in srgb, var(--green) 40%, var(--border)); }
.rodwell-result[data-status="borderline"] { background: var(--yellow-soft); border-color: color-mix(in srgb, var(--yellow) 40%, var(--border)); }
.rodwell-result[data-status="altered"], .rodwell-result[data-status="critical"] { background: var(--red-soft); border-color: color-mix(in srgb, var(--red) 40%, var(--border)); }
.rodwell-score { font-size: 2.4rem; font-weight: 950; letter-spacing: -.04em; }

.biochemical-groups { display: grid; gap: 16px; }
.input-group { padding: 17px; border: 1px solid var(--border); border-radius: 18px; background: var(--surface-soft); }
.input-group h3 { margin: 0 0 13px; font-size: 1rem; }
.input-grid { display: grid; grid-template-columns: repeat(3, minmax(0,1fr)); gap: 13px; }

.biobank-note { margin: 14px 0 0; color: var(--muted); font-size: .83rem; }
.biomarker-results { display: grid; grid-template-columns: repeat(2, minmax(0,1fr)); gap: 13px; margin-top: 18px; }
.biomarker-result {
  border: 1px solid var(--border);
  border-left: 5px solid #8795aa;
  border-radius: 17px;
  padding: 16px;
  background: var(--surface);
}
.biomarker-result[data-status="normal"] { border-left-color: var(--green); background: var(--green-soft); }
.biomarker-result[data-status="borderline"] { border-left-color: #d99a00; background: var(--yellow-soft); }
.biomarker-result[data-status="altered"], .biomarker-result[data-status="critical"] { border-left-color: var(--red); background: var(--red-soft); }
.biomarker-result[data-status="info"] { border-left-color: var(--primary); }
.biomarker-result-head { display: flex; justify-content: space-between; gap: 12px; align-items: flex-start; }
.biomarker-result h3 { margin: 0; font-size: .98rem; }
.formula { margin: 3px 0 0; color: var(--muted); font-size: .76rem; }
.status-pill { flex: 0 0 auto; padding: 5px 8px; border-radius: 999px; background: color-mix(in srgb, var(--surface) 78%, transparent); border: 1px solid var(--border); font-size: .7rem; font-weight: 900; }
.biomarker-value { font-size: 1.7rem; font-weight: 950; letter-spacing: -.03em; margin-top: 14px; }
.biomarker-explanation { margin: 5px 0 0; color: var(--muted); font-size: .84rem; }
.serial-crp { margin-top: 14px; padding: 13px 15px; border-radius: 14px; font-weight: 750; }
.serial-crp[data-status="normal"] { background: var(--green-soft); color: var(--green); }
.serial-crp[data-status="altered"] { background: var(--red-soft); color: var(--red); }

.report-identification { display: grid; grid-template-columns: repeat(2, minmax(0,1fr)); gap: 10px; margin-bottom: 14px; }
.report-identification div { padding: 12px; border: 1px solid var(--border); border-radius: 13px; background: var(--surface-soft); }
.report-identification span { display: block; color: var(--muted); font-size: .72rem; text-transform: uppercase; letter-spacing: .04em; }
.report-identification strong { display: block; margin-top: 3px; }
.report-module-grid { display: grid; grid-template-columns: repeat(3, minmax(0,1fr)); gap: 12px; margin: 16px 0; }
.report-module { min-height: 115px; padding: 15px; border: 1px solid var(--border); border-radius: 16px; background: color-mix(in srgb, var(--surface) 84%, transparent); }
.report-module span { display: block; color: var(--muted); font-size: .82rem; margin-top: 5px; }
.report-reasons { margin: 12px 0 0; padding-left: 21px; }
.report-reasons li { margin: 4px 0; }

.references { columns: 2; column-gap: 32px; padding-left: 20px; }
.references li { break-inside: avoid; margin-bottom: 10px; color: var(--muted); font-size: .82rem; }
.references a { overflow-wrap: anywhere; }
.footer { margin-top: 26px; border-top: 1px solid var(--border); background: var(--surface); }

@media (max-width: 900px) {
  .tab-nav { grid-template-columns: repeat(2, minmax(0,1fr)); }
  .clinical-grid, .result-metrics, .report-module-grid { grid-template-columns: 1fr; }
  .input-grid { grid-template-columns: repeat(2, minmax(0,1fr)); }
  .biomarker-results { grid-template-columns: 1fr; }
  .references { columns: 1; }
}

@media (max-width: 620px) {
  .calped-shell { width: min(100% - 18px, 1180px); }
  .header-links { display: none !important; }
  .hero { padding-top: 24px; }
  .tab-nav { position: sticky; top: 72px; z-index: 20; gap: 6px; padding: 6px; }
  .tab-button { min-height: 58px; padding: 8px; font-size: .78rem; }
  .tab-button span { display: none; }
  .section-card { padding: 16px; border-radius: 18px; }
  .input-grid, .report-identification { grid-template-columns: 1fr; }
  .clinical-option { min-height: auto; }
  .biomarker-result-head { display: block; }
  .status-pill { display: inline-block; margin-top: 8px; }
  .btn-primary, .btn-secondary, .btn-danger { width: 100%; }
  .action-row { display: grid !important; grid-template-columns: 1fr; }
}

@media print {
  @page { size: A4; margin: 12mm; }
  html, body { background: #fff !important; color: #000 !important; font-size: 10pt; }
  .no-print, .calped-header, .tab-nav, #globalMessage, footer { display: none !important; }
  body.print-report main > *:not(#reportPrintArea) { display: none !important; }
  #reportPrintArea, #reportPrintArea * { visibility: visible !important; }
  #reportPrintArea { display: block !important; margin: 0 !important; }
  .card, .section-card, .result-box, .report-module, .report-identification div {
    box-shadow: none !important;
    background: #fff !important;
    color: #000 !important;
    border-color: #aaa !important;
  }
  .section-card { padding: 0 !important; border: 0 !important; }
  .references { columns: 1; }
}